A Schistosomiasis Model with Praziquantel Resistance

A Schistosomiasis Model with Praziquantel Resistance

A compartmental model is established for schistosomiasis with praziquantel resistance. The model considers the impact of genetic resistance and drug treatment on the transmission of schistosomiasis. We calculate the basic reproductive number and discuss the existence and stability of disease-free equilibrium, boundary equilibrium, and coexistence equilibrium. Our analysis shows that regardless ...

BCG and praziquantel for Schistosomiasis treatment.

Prior study has suggested that praziquantel could be used in lower doses, one-third than the conventional, when associated to BCG in non reactors patients to PPD (N Nohmi et al. 1993, IV International Symposium on Schistosomiasis, p. 165). In schistosomiasis, a higher degree of protective immunity was obtained when BCG was used in combination with a non-living vaccine of schistosomula (SL James...

Human Schistosomiasis Resistance to Praziquantel in China: Should We Be Worried?

The efficacy of praziquantel for the treatment of Schistosoma japonicum in humans is reported from a cross-sectional survey conducted in 33 villages in Sichuan Province. Infection prevalence was found to be 5.7% (185 infected of 3,269 tested) in a region where 44-73% prevalence was found 9 years before. Collected miracidia were subjected to an in vitro test of praziquantel susceptibility. An ef...

Treatment of patients with schistosomiasis mansoni: a double blind clinical trial comparing praziquantel with oxamniquine.

A double-blind clinical trial involving 120 patients with chronic schistosomiasis was carried out to compare the tolerability and efficacy of praziquantel and oxamniquine. The patients were randomly allocated into two groups. One was treated with praziquantel, 55 mg/kg of body weight CBWT), and the other one with oxamniquine, 15mg/kg bwt, administered in a single oral dose. The diagnosis and th...

Synergy of concurrent low dose oxamniquine and praziquantel in schistosomiasis.